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肾小球肾炎合并咯血的称为Goodpasture综合征。在相当于3/4有肾小球基底膜(GBM)自身抗体的患者中见到,其余的只为肾炎。自身抗体引起的肺损害伴抗GBM肾炎是有充分证据的。IgG和补体的线状沉积,在受累肺脏的肺泡间隔中出现,此外,从受累肾和肺洗脱出来的IgG应用于肺的切片时,即与肺泡的基底膜呈线状结合。但将这种相同的洗脱出来的免疫球蛋白给猴子作静脉注射时,却不能与ABM结合或产生出血性肺炎。尽管如此,在GBM却引起IgG线状沉积的新月体肾小球肾炎。同样,在绵羊和
Glomerulonephritis combined with hemoptysis is called Goodpasture’s syndrome. Seen in patients equivalent to 3/4 GBM autoantibodies, the rest were nephritis alone. There is ample evidence that autoantibodies cause lung damage with anti-GBM nephritis. Linear deposition of IgG and complement occurs in the alveolar space of affected lungs. In addition, IgG eluted from affected kidneys and lungs binds linearly to the basement membrane of the alveoli when applied to sections of the lung. However, when such an identical eluted immunoglobulin is administered intravenously to a monkey, it can not bind to ABM or cause hemorrhagic pneumonia. In spite of this, glomerular glomerulonephritis caused by IgG linear deposition in GBM. Again, in sheep and