【摘 要】
：
In order to reduce implant-related infections and improve early osseointegration,we performed HF+anodic oxidation on the surface of the new antibacterial Ti-Cu alloy to make the titanium-based implants have a micro/submicron structure.On this basis,a seri
【机 构】
：
School and Hospital of Stomatology,China Medical University,Shenyang 110001,China;Liaoning Provincia
论文部分内容阅读
In order to reduce implant-related infections and improve early osseointegration,we performed HF+anodic oxidation on the surface of the new antibacterial Ti-Cu alloy to make the titanium-based implants have a micro/submicron structure.On this basis,a series of surface-modified Ti-xCu alloys with different Cu contents (3,5 and 7 wt％) were fabricated and a comprehensive study was conducted on MC3T3-E1 cell adhesion,proliferation,apoptosis and its antibacterial activity against Staphylococcus aureus.Results showed that the Ti-xCu alloys by HF etching + anodized possessed multifunctional characteristics of antibiofilm and antibacterial abilities,excellent biocompatibility and osteogenesis promoting abilities.Increment of Cu content significantly contributed to the antibacterial and osteogenic properties of HF etching + anodized Ti-Cu alloys.Cell proliferation rates of HF etching + anodized Ti-7Cu alloys were lower than those of Ti-3Cu and Ti-5Cu alloys,while the early cell apoptosis rates were higher than Ti-3Cu and Ti-5Cu groups.All the above results finally presented that the HF etching + anodized Ti-5Cu alloy exhibited extremely strong antibacterial properties,good biological compatibility and osteogenic ability,as well as the most excellent ductility and corrosion resistance,providing a great potential application for the future dental implantation.
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