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目的:研制冻干人尿中镉标准物质。方法:采集正常人尿经处理后作为基质，通过加标、混匀、分装、冷冻干燥制备而成；经均匀性检验、稳定性考察后，由7家实验室采用2种方法进行合作定值，并进行不确定度评定。结果:研制的标准物质最小取样量为0.20 ml，2个水平的均匀性检验值n F分别为1.69和1.49，差异无统计学意义（n P>0.05）。冻干标准物质在≤4 ℃下保存可稳定12个月，复溶后的标准物质溶液在4 ℃条件下可稳定7 d。2个水平的标准量值及不确定度分别为（5.34±0.34）μg/L和（15.47±0.72）μg/L（n k=2）。n 结论:研制的标准物质各项指标符合国家相关要求，可用于人尿中镉检测方法验证及相关样品检测。“,”Objective:To develop the certified reference material of cadmium in human urine (freeze-dried) .Methods:Urine were collected from normal human, and then the urine samples were prepared by adding standard, mixing, packing and freeze-drying. After homogeneity test and stability test, the urine samples were determined by two methods in seven independent laboratories, the uncertainty of the certified reference material was evaluated.Results:Take at least 0.20 ml solution of the certified reference material per use, and the homogeneity is good. The freeze-dried materials can be kept stable for 12 months at ≤4 °C, and the re-dissolved reference materials can be stabilized for 7 days at 4 °C. The standard values and uncertainty of the two levels were (5.34±0.34) μg/L and (15.47±0.72) μg/L, respectively.Conclusion:The standards met the requirements of national standards, and can be used to verify the methods of detecting cadmium in human urine and to detect the samples.