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目的观察胸腺五肽联合伊曲康唑治疗复发性外阴阴道念珠菌病的临床疗效。方法 60例患者随机分为2组,治疗组采用肌内注射胸腺五肽注射液1mg,隔日1次,10次为1疗程,同时口服伊曲康唑胶囊200mg,连服7d。对照组仅口服伊曲康唑胶囊,方法同治疗组。2组均于下次月经周期第1天开始重复上次治疗,且连续巩固治疗3个月经周期。2组均于治疗结束停药后1、3、6个月复诊并记录患者临床症状及体征、不良反应及真菌学检查结果,以综合评价疗效。结果 30例治疗组患者治疗结束1、3、6有效率分别为75.00%、80.00%、70.00%,明显高于对照组(P<0.05)。结论胸腺五肽联合伊曲康唑治疗复发性外阴阴道念珠菌病安全有效,可降低复发率。
Objective To observe the clinical efficacy of thymopentin combined with itraconazole in the treatment of recurrent vulvovaginal candidiasis. Methods Sixty patients were divided into two groups at random. The treatment group received intramuscular injection of thymopentin 1mg every other day for 10 times as a course of treatment. At the same time, oral administration of itraconazole capsule 200mg for 7 days. Control group only oral itraconazole capsules, the same method as the treatment group. Both groups began to repeat the last treatment on the first day of the next menstrual cycle and continued to consolidate for 3 menstrual cycles. The two groups were followed up at 1,3,6 months after the end of treatment and recorded the clinical symptoms and signs, adverse reactions and mycological findings in order to evaluate the efficacy. Results The effective rates of the 1,3 and 6 treatment groups in the 30 treatment groups were 75.00%, 80.00% and 70.00%, respectively, which were significantly higher than those in the control group (P <0.05). Conclusion Thymopentin combined with itraconazole in the treatment of recurrent vulvovaginal candidiasis is safe and effective, can reduce the recurrence rate.