抗真菌新药特比萘芬对家兔皮肤慢性毒性研究

• 作 者: 李永金 阚士雪 张崇高
• 出 处: 镇江医学院学报
• 发表日期: 1995年02期
• 关键词: 特比萘芬 慢性毒性 家兔皮肤 轻度红斑 组织学检查 充血红斑 青紫蓝 真菌感染 毒性试验 血液学检查

用特比萘芬对青紫蓝家兔连续进行一个月皮肤敷药毒性试验，观察动物所产生的毒性反应情况，为临床局部用药提供安全方面依据，试验分设基质对照，５％、１０％和２０％四组，结果敷药局部皮肤２０％组呈明显充血红斑，并伴以轻度水肿，组织学检查见皮肤角化层略增厚；１０％组出现明显红斑，５％组１／３兔出现轻度红斑，全身情况、血液学参数、血液生化指标、组织检查与对照组相比均未见明显差别。

Use terbinafine on Qing Zhao blue rabbits continuously for one month dressing toxicity test to observe the toxicity of animals produced by the situation for the clinical use of drugs to provide a safe basis, the test divided by matrix control, 5%, 10% and 20 % Of the four groups, the results of the topical application 20% of the skin was marked congestion of erythema, accompanied by mild edema, histological examination of the keratinized layer of skin thickening; 10% of the group showed significant erythema, 5% group of 1/3 rabbits Mild erythema occurred, systemic conditions, hematological parameters, blood biochemical indicators, tissue examination and control group were no significant differences.