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随着经济、社会、文化发展和我国计划生育新政出台,有生育子代意愿的高龄男性越来越多,高龄男性对生殖结局的影响应引起医学界高度重视。本文对高龄男性生育能力及子代健康风险进行了总结,发现高龄男性生育能力下降,辅助生殖成功率降低,女方流产率上升,与年龄相关的精子基因突变及遗传性疾病增加,精子表观遗传学改变可能引起子代易患精神分裂症、儿童孤独症,甚至恶性肿瘤等疾病。建议高龄男性在准备生育前应进行孕前咨询及相关医学检测;由于各种原因暂时不想生育的年青男性可以到人类精子库进行生殖保险,这样完全可以避免男性高龄引起的子代健康风险。
With the economic, social and cultural development and the introduction of the New Deal of Family Planning in China, more and more elderly men and women have the intention of having children and giving birth. The impact of older men on reproductive outcomes should draw great attention from the medical community. This article summarizes the reproductive capacity of older men and their offspring’s health risks. It is found that fertility decline of aged men, assisted reproductive success rate, women’s miscarriage rate increased, age-related sperm genetic mutations and genetic diseases increased, sperm epigenetic Changes in learning may lead to offspring prone to schizophrenia, autism in children and even malignant tumors and other diseases. It is recommended that older men should consult before pregnancy and relevant medical tests before preparing for childbearing. Young men who temporarily do not want to give birth for various reasons may go to the human sperm bank for reproductive insurance so as to completely avoid the risk of male offspring’s health caused by the elderly.