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最近10余年来,呼吸肌疲劳在慢性呼吸衰竭发生过程中的作用逐渐受到重视,对其病理生理改变、生化改变、临床诊断方法及治疗措施等均进行了研究。本文简述近年来有关呼吸肌疲劳治疗研究的部分文献。一、药物治疗 (一)茶碱类茶碱类是目前研究较多的药物,多认为其具有增强呼吸肌收缩力、延缓疲劳发生、加快疲劳恢复的作用。Viires等采用大鼠单个膈肌纤维进行体外试验,15mg/L浓度的氨茶碱使其纠转收缩力增强11%。Delbono等用膈肌束试验结果与此相似。Kolbeck等观察10~(-4)mol/L茶碱对大鼠整块膈肌的作用,结果用药组收缩力较对照者增加15%;经过连续10分钟疲劳刺激后,用药组收缩力较对照组高26%。D-vito
In recent 10 years, the role of respiratory muscle fatigue in the occurrence of chronic respiratory failure has gradually been taken seriously, and its pathophysiological changes, biochemical changes, clinical diagnosis methods and treatment measures were studied. This article summarizes some of the recent literature on the treatment of respiratory muscle fatigue. First, the drug treatment (a) Theophylline Theophylline is currently more studied drugs, and more that it has to enhance respiratory muscle contractility, delay fatigue, speed up the role of fatigue recovery. Viires and other rats with a single diaphragmatic muscle fibers for in vitro experiments, 15mg / L concentration of aminophylline to correct contractility increased by 11%. Delbono and other use of the diaphragm beam test results similar. Kolbeck et al observed the effects of 10 ~ (-4) mol / L theophylline on the whole diaphragm in rats, and the contractile force of the treatment group increased by 15% compared with that of the control group. After 10-minute continuous fatigue stimulation, the contractile force of the treated group was higher than that of the control group High 26%. D-vito