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目的:探讨冻融胚胎移植周期中胚胎复苏时间对妊娠结局的影响。方法:回顾分析行冻胚移植(FET)的206对夫妇共248个周期,根据解冻时间的不同分为A组(对照组):排卵后2～3d或注射黄体酮3～4d后解冻,培养2h移植;B组(实验组):提前1d解冻,培养20h移植。比较各组间患者一般资料、复苏胚胎存活率、完整率、临床妊娠率、胚胎着床率和流产率。结果:A、B组间患者年龄、不孕年限、不孕原因、继发不孕所占比例、第3日冷冻胚胎比例、冷冻胚胎数、移植时内膜厚度、优胚数、胚胎复苏存活率、完整率、平均移植胚胎数均未见差异,而B组临床妊娠率和胚胎着床率显著高于A组(46.36%、25.29%vs30.88%、13.54%,P<0.05),组间流产率未见差异。过夜培养后有胚胎生长组临床妊娠率高于无生长组(49.47%vs26.67%,P>0.05)。结论:冻胚移植周期中提前解冻可以改善妊娠结局。
Objective: To investigate the effect of embryo recovery time on the outcome of pregnancy during the period of frozen-thawed embryo transfer. Methods: A total of 206 cycles of frozen embryo transfer (FET) were retrospectively analyzed. A total of 248 cycles were divided into group A (control group) according to thawing time: thawed after 2-3 days of ovulation or 3-4 days after injection of progesterone 2h transplantation; Group B (experimental group): thawed 1d in advance and cultured for 20h. The general data of patients, resuscitation embryo survival rate, complete rate, clinical pregnancy rate, embryo implantation rate and abortion rate were compared between groups. Results: The age of patients, age of infertility, the causes of infertility, the proportion of secondary infertility, the proportion of frozen embryos on the third day, the number of frozen embryos, the thickness of the intima after transplantation, the number of excellent embryos and the survival of the embryo resuscitation The rates of complete pregnancy, pregnancy rate and embryo implantation rate in group B were significantly higher than those in group A (46.36%, 25.29% vs 30.88%, 13.54%, P <0.05) No difference between abortion rates. The clinical pregnancy rate in embryo growth group after overnight culture was higher than that in non-growth group (49.47% vs26.67%, P> 0.05). Conclusion: Early thawing of frozen embryo transfer can improve pregnancy outcomes.