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目的 :探讨放化疗综合治疗对中晚期食管癌的治疗作用。方法:将 4 8例中晚期食管癌病人随机分为综合组和单放组各 2 4例。综合组在放疗前和放疗初进行 2个周期 PFP方案化疗 ,两组病人均常规放疗 ,总剂量 6 5Gy。结果:(1)两组病人治疗结束时食道钡餐片评价差别无统计学意义。 (2 )综合组放射性食管炎毒性反应较单放组发生率高且严重。 (3)综合组和单放组 1、2、3、4年生存率分别为 5 8.3%、4 1.7%、2 9.2 %、2 5 .0 %和 5 4 .8%、2 9.2 %、2 5 .0 %、2 0 .8% ,两组生存情况经 log- rank检验差别无统计学意义。 (4)综合组和治疗组死于局部复发、未能增加局部控制率 (未控率 )和远处转移率分别是 5 4 .2 %、16 .7%和 5 0 .0 %、2 5 .0 %。 结论:综合治疗未能提高中晚期食管癌的近期疗效和远期疗效 ,未能增加肿瘤局控率和减少远处转移 ,而增加了治疗中放射性食管炎的发生和严重程度
Objective: To explore the radiotherapy and chemotherapy comprehensive treatment of advanced esophageal cancer treatment. Methods: Forty-eight patients with advanced esophageal cancer were randomly divided into two groups (24 cases in each group). The combined group received two cycles of PFP regimen before radiotherapy and radiotherapy, and both groups received conventional radiotherapy at a total dose of 65 Gy. Results: (1) The difference of esophageal barium meal evaluation between the two groups was not statistically significant at the end of treatment. (2) The combined group of radioactive esophagitis toxicity than the single group the incidence of high and serious. (3) The 1, 2, 3, 4-year survival rates of the combined group and the single group were 53.3%, 47.1%, 29.2%, 25.0% and 54.4%, 29.2%, 2 5 .0%, 20.8%, two groups of survival by log-rank test difference was not statistically significant. (4) The combination group and the treatment group died of local recurrence, failed to increase the local control rate (uncontrolled rate) and distant metastasis rate were 54.2%, 16.7% and 50.0%, 25 .0%. Conclusion: The comprehensive treatment failed to improve the short-term and long-term efficacy of esophageal cancer in the late stage, failed to increase the local control rate and reduce distant metastasis, and increased the incidence of esophagitis in the treatment and severity