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目的:分析在手足口病患儿的治疗中联合应用喜炎平与阿昔洛韦的有效性。方法:选在惠州市龙门县人民医院2016年7月至2017年7月治疗的手足口病患儿102例,依据用药方式的不同分成联合组与单治组,每组51例,单治组患儿单纯应用喜炎平治疗,联合组在单治组治疗的基础上加用阿昔洛韦治疗,比较两组患儿临床疗效。结果:治疗后,两组患儿肿瘤坏死因子-α(TNF-α)、白细胞介素-10(IL-10)、白细胞介素-6(IL-6)、干扰素γ(INF-γ)指标均发生显著改善,且联合组改善幅度较大,组间比较,差异具有统计学意义(P<0.05);联合组患儿临床治疗的总有效率明显比单治组高,组间比较,差异具有统计学意义(P<0.05)。结论:在手足口病的患儿治疗中联合应用喜炎平与阿昔洛韦能够提高临床治疗的效果。
OBJECTIVE: To analyze the efficacy of combined use of Xiyanping and acyclovir in the treatment of children with hand-foot-mouth disease. Methods: A total of 102 children with HFMD who were treated in Longmen People’s Hospital of Huizhou City from July 2016 to July 2017 were divided into two groups according to the mode of treatment: combination group and monotherapy group, 51 cases in each group, Treatment of children with simple Xiyanping treatment group, combined with acyclovir alone treatment group based on the treatment group, the clinical efficacy of two groups were compared. Results: After treatment, the levels of TNF-α, IL-10, IL-6, INF-γ, (P <0.05). The total effective rate of clinical treatment in children in combination group was significantly higher than that in single-treatment group, and the differences between two groups were statistically significant (P <0.05) The difference was statistically significant (P <0.05). Conclusion: The combination of Xiyanping and acyclovir in the treatment of children with hand-foot-mouth disease can improve the clinical effect.