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目的探讨妊娠期肝内胆汁淤积症(ICP)脐血流比值对新生儿预后的影响。方法观察32例ICP孕妇的肝功能(TBA、ALT、AST),围产儿结局(孕周、新生儿体重,胎儿窘迫、新生儿窒息、羊水胎粪污染、新生儿吸入性肺炎和早产)和脐血流比值对围产儿预后等情况,并与同期分娩32例正常孕妇进行比较分析。结果 (1)ICP组TBA、ALT、AST水平均高于对照组(P<0.01);(2)ICP组胎儿孕周、体重均低于对照组(P<0.05或P<0.01);ICP组胎儿窘迫、新生儿窒息、羊水胎粪污染、新生儿吸入性肺炎和早产的发生率高于对照组(P<0.05或P<0.01);(3)ICP组RI值、S/D值高于对照组(P<0.01),两组PI值差异无显著性(P>0.05)。结论对ICP孕妇早期和定期进行脐动脉血流的测定,有助于加强对ICP孕妇的监测,有助于及早地发现ICP孕妇胎儿宫内不良状态,有利于改善新生儿结局。
Objective To investigate the effect of intrauterine cholestasis of pregnancy (ICP) on the prognosis of newborns. Methods Twenty-two pregnant women with ICP were evaluated for liver function (TBA, ALT, AST), perinatal outcome (gestational age, newborn weight, fetal distress, neonatal asphyxia, amniotic meconium, neonatal aspiration pneumonia and premature delivery) Blood flow ratio of the prognosis of perinatal cases, and with the same period delivery of 32 cases of normal pregnant women were compared. Results (1) The levels of TBA, ALT and AST in ICP group were significantly higher than those in control group (P <0.01). (2) The gestational age and body weight in ICP group were lower than those in control group (P <0.05 or P < The incidence of fetal distress, neonatal asphyxia, meconium-stained amniotic fluid, neonatal aspiration pneumonia and preterm delivery were higher than those in the control group (P <0.05 or P <0.01). (3) The RI and S / The control group (P <0.01), there was no significant difference between the two groups (P> 0.05). Conclusion The determination of umbilical arterial blood flow in early pregnancy and regular pregnancy in pregnant women with ICP is helpful to strengthen the monitoring of ICP pregnant women and help to find out the status of fetal intrauterine pregnancy in ICP pregnant women in advance and to improve the neonatal outcome.