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观察１５例Ⅱ型糖尿病患者（无急性并发症及严重慢性并发症，空腹血糖９．３～２２。３ｍｍｏｌ／Ｌ）、９例正常对照组的２２：００至８：００血清ＴＳＨ浓度的动态变化。结果发现。所有被检者均有血促甲状腺激素（ＴＳＨ）浓度的波动，但糖尿病组血ＴＳＨ高峰时间与正常何照相比明显延迟。提示此类糖尿病患者有夜间下丘脑──垂体──甲状腺轴的改变。
To observe the dynamic changes of serum TSH concentrations in 22 patients with type 2 diabetes mellitus (without acute complications and severe chronic complications, fasting blood glucose of 9.3 ~ 22.3mmol / L) and 9 normal controls from 22:00 to 8:00 . turn out. All subjects had blood thyroid hormone (TSH) concentration fluctuations, but the blood glucose TSH peak time compared with normal control was significantly delayed. Tip of this type of diabetic patients have nighttime hypothalamus ─ ─ pituitary ─ ─ thyroid axis changes.