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五十年代,巴尔干肾病首先被认为是一种致命的慢性肾病。该病特征为肾萎缩,伴有肾皮质曲管的退行性变、间质纤维化和肾小球玻璃样变,肾功能试验结果表明,其主要靶器官是近曲小管。霉菌毒素肾病是在猪和家禽中自然发生的病,地方性肾病与由棕曲霉毒素A(ochratoxin A,OA)引起的猪的肾病肾结构和肾功能的变化是相似的,它们可能有着共同的病因关系。为确定OA是地方性肾病的病因,对病区的食品进行了检查。调查地点选择在南斯拉夫
In the fifties, Balkan kidney disease was first thought to be a deadly chronic kidney disease. The disease is characterized by renal atrophy, with degeneration of renal cortical tubules, interstitial fibrosis and glomerular degeneration, renal function test results show that its main target organ is proximal convoluted tubule. Mycotoxin nephropathy is a naturally occurring disease in pigs and poultry. The endemic nephropathy is similar to the changes in kidney structure and kidney function in porcine kidney caused by ochratoxin A (OA), and they may share a common Etiology. To determine that OA is the cause of endemic kidney disease, the ward’s food was examined. Survey site selection in Yugoslavia