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采用 ELISA 双抗体夹心法对106例 HBV 感染者共146份血清进行前 S1和前 S2抗原同步检测,结果血清前 S 抗原与血清 HBVDNA 密切相关,但并不完全一致;其与血清 HBeAg、PHSA 受体活性及抗 HBc 也具有良好的正相关性。五组不同临床类型 HBV 感染者血清前 S 抗原检出率及相对含量均以 ASC 组最高,SH 组次之,CAH、CPH 和 AH 组均较低。AH 组随疾病恢复、ALT 下降,血清前 S 抗原相对含量下降乃至阴转;CAH 和 CPH 组尽管病情改善、ALT 下降,血清前 S 抗原相对含量并无明显改变;SH 组则无论病情好转或恶化,血清前 S 抗原相对含量均下降。表明连续定量检测血清前 S 抗原可为除 SH 外其它各型乙型肝炎提示预后。作为 HBV 复制和疾病预后观察指标血清前 S1抗原较前 S2抗原敏感。
Pre-S1 and pre-S2 antigens were detected simultaneously in 146 serum samples from 106 patients with HBV infection using ELISA double antibody sandwich method. The results showed that serum pre-S antigen was closely related to serum HBVDNA but not identical with serum HBeAg and PHSA Body activity and anti-HBc also had a good positive correlation. The detection rate and the relative content of pre-S antigen in five groups of patients with different clinical types of HBV infection were the highest in ASC group, followed by SH group, CAH, CPH and AH groups. AH group with the disease recovery, ALT decreased, the relative content of serum pre-S antigen decreased or even negative; CAH and CPH group despite improved disease, ALT decreased, the relative content of serum pre-S antigen did not change significantly; SH group, regardless of the condition improved or worsen , The relative content of serum pre-S antigen decreased. Continuous quantitative detection of serum S-antigen that can be in addition to SH other types of hepatitis B prognosis. As an indicator of HBV replication and disease prognosis, pre-S1 antigen is more sensitive than pre-S2 antigen.