【摘 要】
：
Lanthipeptides are one of the largest groups of ribosomally synthesized and post-translationally mod-ified peptides (RiPPs) and are characterized by the presence of lanthionine (Lan) or methyllanthionine residues (MeLan).Only very few lanthipeptides conta
【机 构】
：
State Key Laboratory of Pharmaceutical Biotechnology,Institute of Functional Biomolecules,School of
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Lanthipeptides are one of the largest groups of ribosomally synthesized and post-translationally mod-ified peptides (RiPPs) and are characterized by the presence of lanthionine (Lan) or methyllanthionine residues (MeLan).Only very few lanthipeptides contain a C-terminal 2-aminovinyl-cysteine (AviCys) mo-tif,but all of them show potent antibacterial activities.Recent advances of genome sequencing led to the rapid accumulation of new biosynthetic gene clusters (BGCs) for lanthipeptides.In this study,through our genome mining strategy,we found the AviCys containing lanthipeptides are widespread in the bacte-rial kingdom.A lanthipeptide-type biosynthetic gene cluster was identified from public bacterial genome database.Two new lanthipeptides,daspyromycins A and B (1 and 2) containing AviCys motif,along with two degraded products,daspyromycins C and D (3 and 4),were obtained after hetemlogous expression of the gene cluster in Streptomyces albus J1074.Daspyromycins A and B showed potent antimicmbial activity against a spectrum of Gram-positive and-negative bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE).
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