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目的了解我国石化企业周边居民体内多种多环芳烃(PAHs)的内暴露水平与分布特征。方法于2012年7月选取我国南方某大型石化企业,采用系统抽样法在石化企业周边收集到当地≥45岁居民的尿样。采用快速液相色谱-三重四级杆串联质谱仪检测多环芳烃羟基代谢物(OH-PAHs)。结果本研究共调查165名≥45岁石化企业周边居民,男、女性分别为81、84人,以45~64岁居民为主,占62.82%(102/165)。职业构成主要以农民为主,占49.09%(81/165)。检出2-羟基萘(2-OHN)、1-羟基萘(1-OHN)、2-羟基芴+3-羟基芴(2-+3-OHF)、2-羟基菲(2-OHPhe)、3-羟基菲(3-OHPhe)、4-羟基菲(4-OHPhe)、1-羟基菲+9-羟基菲(1-+9-OHPhe)和1-羟基芘(1-OHP)10种OH-PAHs,其浓度的中位数分别为:1.83、1.34、0.51、0.14、0.21、0.07、0.69、0.25μmol/mol肌酐,除2-OHN和1-+9-OHPhe之间无相关性,其他各OH-PAHs间均呈正相关关系(P<0.05或P<0.01),相关系数在0.20~0.76之间。除OHPhes外,吸烟人群体内的其他OH-PAHs含量均高于不吸烟人群(P<0.05或P<0.01)。结论石化厂区域中老年居民尿液样本中以总羟基萘(1-OHN和2-OHN)为主,这与石化厂多环芳烃的污染主要是低环的化合物为主一致。
Objective To understand the internal exposure and distribution characteristics of polycyclic aromatic hydrocarbons (PAHs) in residents around petrochemical enterprises in China. Methods In July 2012, a large-scale petrochemical enterprise in southern China was selected. Urine samples of residents ≥45 years of age were collected by petrochemical enterprises by systematic sampling method. Polycyclic aromatic hydroxy metabolites (OH-PAHs) were detected by a rapid liquid chromatography-triple quadrupole tandem mass spectrometer. Results A total of 165 residents aged ≥45 years of petrochemical enterprises were investigated in this study. There were 81,84 men and women, accounting for 62.82% (102/165) of residents aged 45-64 years. The occupational composition is mainly dominated by peasants, accounting for 49.09% (81/165). (2-OHN), 1-hydroxynaphthalene (1-OHN), 2-hydroxyfluorene + 3-hydroxyfluorene (2- + 3-OHF), 2-OHPhe, 10 OH species such as 3-OHPhe, 4-OHPhe, 1-OHF + 9-OHPhe and 1- -PAHs, the median concentrations were: 1.83,1.34,0.51,0.14,0.21,0.07,0.69,0.25μmol / mol creatinine, except for 2-OHN and 1- + 9-OHPhe no correlation between the other There was a positive correlation between OH-PAHs (P <0.05 or P <0.01) and the correlation coefficient was between 0.20 and 0.76. Except OHPhes, the content of other OH-PAHs in smokers was higher than that in non-smokers (P <0.05 or P <0.01). Conclusion The total amount of hydroxynaphthalene (1-OHN and 2-OHN) in the urine samples of middle-aged and elderly inhabitants in the petrochemical plant area is the main one. This is consistent with the fact that the pollution of PAHs in petrochemical plants is dominated by low-cyclic compounds.