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作者采用气管内非暴露式染尘,给大鼠一次性注入新康短纤维温石棉粉尘混悬液1ml(含石棉25mg),对照组注入等量生理盐水,光镜及电镜下观察其细支气管肺泡炎的病理改变。结果显示:染尘后3天,实验组大鼠肺内细支气管肺泡炎最显著,同时伴有气腔上皮和基底膜的损伤;7天后,炎性渗出物开始为巨噬细胞肉芽肿所代替;14～45天后,逐渐出现附壁型或腔内型纤维化。由此表明:国产新康短纤维温石棉具有肯定的致肺泡炎和致纤维化作用。
The authors used intratracheal non-exposure to dust in rats once a single injection of Xin Kang staple fiber chrysotile asbestos dust suspension 1ml (containing asbestos 25mg), the control group was injected with the same amount of saline, light and electron microscopy of its bronchioles Alveolitis pathological changes. The results showed that after 3 days of dying, the bronchioloalveolar pneumonitis in the lungs of the experimental group was the most significant, accompanied by the damage of the air cavity epithelium and the basement membrane. After 7 days, the inflammatory exudate started to be the macrophage granuloma Instead of 14 to 45 days, gradually appeared in type or endoluminal fibrosis. This shows that: China Xin Kang short staple fiber chrysotile has a positive cause of alveolar inflammation and fibrosis.