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目的 研究乌拉地尔对吗啡依赖新生雄性大鼠肾上腺皮质酶组织化学影响，为临床戒毒治疗提供形态学依据。方法 用皮下注射吗啡建立吗啡依赖模型，侧脑室注射乌拉地尔进行戒断。结果 吗啡依赖大鼠肾上腺皮质束状带和网状带琥珀酸脱氢酶（ＳＤＨ）和３β－羟基类固醇脱氢酶（３β－ＨＳＤ）的活性减弱（ Ｐ＜ ０．０１），侧脑室注射乌拉地尔成瘾大鼠ＳＤＨ 和３β－ＨＳＤ的活性增强（ Ｐ＜ ０．０１）。结论 乌拉地尔可通过改变大鼠下丘脑－垂体－肾上腺轴，减轻对吗啡依赖和耐受的产生。
Objective To study the effects of urapidil on the histochemistry of adrenocortical enzymes in morphine-dependent neonatal male rats and to provide morphological evidence for clinical drug treatment. Methods Morphine-dependent model was established by injecting morphine subcutaneously. The lateral ventricle was injected with urapidil for withdrawal. Results The activity of morphine-dependent adrenal cords and reticulocytes with succinate dehydrogenase (SDH) and 3β-hydroxysteroid dehydrogenase (3β-HSD) decreased (P <0.01) The activities of SDH and 3β-HSD in addicted rats were increased (P <0.01). Conclusion Urapidil can reduce the morphine dependence and tolerance by changing the hypothalamic-pituitary-adrenal axis in rats.