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目的探讨成都市成华区接受艾滋病高效抗病毒治疗的患者的治疗效果。方法利用国家艾滋病抗病毒治疗信息系统,以2005—2015年成华区接受抗病毒治疗的患者作为研究对象,统计分析其治疗前后CD4+T淋巴细胞计数水平,评价其治疗效果。结果成都市成华区2005—2015年接受艾滋病抗病毒治疗的患者共有1 304例,入组治疗时年龄最小为7岁,年龄最大为85岁,平均(35.21±12.89)岁,以男性为主,占90.34%;婚姻状况以未婚为主,占59.51%;感染途径以同性性传播为主,占57.75%。随着治疗时间的延长,CD4+T淋巴细胞计数明显上升,差异有统计学意义(t=30.247,P<0.05),治疗时间超过5年的患者,CD4+T淋巴细胞计数均值从基线的(229.86±146.70)个/mm~3达到(404.09±179.31)个/mm~3。随着治疗时间的延长,CD4+T淋巴细胞计数≥350个/mm~3比例随着治疗时间的延长而增加,而<200个/mm~3者则随着治疗时间的延长而减少。结论成都市成华区艾滋病抗病毒治疗有效提高了CD4+T淋巴细胞计数水平,治疗效果显著。
Objective To investigate the treatment effect of Chengdu Chenghua AIDS-resistant antiviral therapy patients. Methods According to the information system of national AIDS antiviral therapy, taking the patients receiving antiretroviral therapy in Chenghua District from 2005 to 2015 as the research object, the level of CD4 + T lymphocyte count before and after treatment was statistically analyzed to evaluate the therapeutic effect. Results A total of 1 304 patients were admitted to Chenghua District in Chengdu from 2005 to 2015. The minimum age of the patients was 7 years old and the age was 85 years old (average 35.21 ± 12.89 years) Accounting for 90.34%. The main marital status was unmarried, accounting for 59.51%. The main route of transmission was homosexual transmission, accounting for 57.75%. With the prolongation of treatment time, the counts of CD4 + T lymphocytes increased significantly (t = 30.247, P <0.05). The average CD4 + T lymphocyte count of patients with more than 5 years treatment ranged from 229.86 ± 146.70) / mm ~ 3 reached (404.09 ± 179.31) / mm ~ 3. With the extension of treatment time, the proportion of CD4 + T lymphocyte count ≥ 350 / mm ~ 3 increased with the prolongation of treatment time, while those with <200 / mm ~ 3 decreased with the prolongation of treatment time. Conclusion The antiviral treatment of HIV / AIDS in Chenghua District of Chengdu effectively raised the level of CD4 + T lymphocyte count and had a significant therapeutic effect.