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目的:探讨血清骨保护素(OPG)、可溶性核因子κB受体活化因子配体(sRANKL)水平与急性冠状动脉综合征(ACS)的关系。方法:选择稳定型心绞痛(SAP)组17例,不稳定型心绞痛(UAP)组36例,急性心肌梗死(AMI)组8例,对照组27例,所有患者均行冠状动脉造影。采用酶联免疫吸附法(ELLSA)检测患者血清OPG、sRANKL水平。结果:AMI组和UAP组的血清OPG、sRANKL水平比较差异无统计学意义(P>0.05),但这2组患者血清OPG水平较SAP组和对照组明显增高,血清sRANKL水平较SAP组和对照组明显降低,差异均有统计学意义(P<0.05),SAP组和对照组差异有统计学意义(P>0.05)。结论:血清OPG水平的升高、sRANKL水平的降低提示缺血心肌发生了急性炎症反应,可能与粥样斑块的不稳定性有关。
Objective: To investigate the relationship between serum osteoprotegerin (OPG), sRANKL and acute coronary syndrome (ACS). Methods: Seventeen patients with stable angina pectoris (SAP), 36 patients with unstable angina pectoris (UAP), 8 patients with acute myocardial infarction (AMI) and 27 patients with control group were enrolled in this study. All patients underwent coronary angiography. Serum levels of OPG and sRANKL were detected by enzyme-linked immunosorbent assay (ELLSA). Results: There was no significant difference in serum OPG and sRANKL levels between AMI group and UAP group (P> 0.05). However, serum OPG levels in both groups were significantly higher than those in SAP group and control group, serum sRANKL levels were significantly higher than those in SAP group and control group (P <0.05). The difference between the SAP group and the control group was statistically significant (P> 0.05). Conclusion: The increase of serum OPG level and the decrease of sRANKL level suggest that the acute inflammatory reaction occurs in ischemic myocardium, which may be related to the instability of atherosclerotic plaque.