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氯铬酸吡啶(pyridinium chlorochromate),简称PCC,首先是E.J.Corey于1975年进行开发性研究之后发现的一种新的选择性氧化剂。主要用于:醇类氧化成醛(酮);碳水化合物中局部羟基选择性氧化;硼烷、肟(脱肟反应)氧化成羰基化合物;烯基叔醇直接氧化成α,β-不饱和醛;还可以使烯醇直接氧化成酯或内酯,等等。PCC与其它常用的含铬氧化剂如jons试剂、Collins试剂等比较,它具有氧化能力较强,选择性好,氧化过程中底物分子的烯键不受影响等特点,而且操作简便。另外,由于PCC的酸性较弱,因此那些对酸不稳定的基团在氧化时仍可得以保存。
The pyridinium chlorochromate, or PCC for short, was first identified as a new, selective oxidant discovered by E. J. Corey in 1975 for developmental research. Mainly used for: alcohol oxidation of aldehydes (ketones); selective partial oxidation of carbohydrates hydroxyl; borane, oxime (oxime reaction) oxidation of carbonyl compounds; alkenyl tertiary alcohol is directly oxidized to α, β-unsaturated aldehydes It is also possible to oxidize the enol directly to an ester or lactone, and the like. PCC and other commonly used chromium-containing oxidants such as jons reagent, Collins reagent, etc., it has a strong oxidation, selectivity, oxidation of the substrate molecules of the ethylenic bond is not affected and so on, and easy to operate. In addition, due to the weak acidity of PCC, those acid labile groups are still preserved when oxidized.