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目的：研究ＮＯ在脑缺血再灌注中对局部脑血流量和脑水肿的影响，为临床改进脑缺血的治疗提供新思路。方法：采用拴线法大鼠ＭＣＡ缺血再灌注模型，利用外源性ＮＯ前体（Ｌ－ａｒｇ）和ＮＯＳ抑制剂（Ｌ－ＮＡＭＥ）。将４２只Ｗｉｓｔａｒ大鼠随机分组，在ｒ－ＣＢＦ组和脑水肿两大组中分别设有：缺血再灌注盐水组，再灌注Ｌ－ａｒｇ组，再灌注Ｌ－ＮＡＭＥ组。结果：与盐水组比较，Ｌ－ａｒｇ组ｒ－ＣＢＦ明显升高（Ｐ＜０．０５），脑水肿显著减轻（Ｐ＜０．０５）；Ｌ－ＮＡＭＥ组ｒ－ＣＢＦ明显降低（Ｐ＜０．０５），脑水肿显著加重（Ｐ＜０．０５）。结论：ＮＯ对缺血再灌注脑组织有保护性作用。
Objective: To study the effect of nitric oxide on cerebral blood flow and cerebral edema in cerebral ischemia-reperfusion, and to provide new ideas for the clinical treatment of cerebral ischemia. Methods: MCA model of ischemia-reperfusion in rats was established by tethering method. Exogenous NO precursor (L-arg) and NOS inhibitor (L-NAME) were used. Forty-two Wistar rats were randomly divided into two groups: ischemia reperfusion saline group, L-arg reperfusion group and L-NAME reperfusion group. Results: Compared with saline group, r-CBF in L-arg group was significantly increased (P <0.05), cerebral edema was significantly reduced (P <0.05), r-CBF in L-arginine group was significantly decreased .05), cerebral edema significantly increased (P <0.05). Conclusion: NO has a protective effect on cerebral ischemia reperfusion.