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本文测定了36例新诊断、未使用过外源胰岛素的IDDM患者的血清胰岛细胞抗体(ICA)、血清胰岛素自身抗体(IAA)及血清C肽和胰岛素水平,并以72例新诊断的NIDDM和36例正常人作为对照。研究表明:自身免疫在IDDM病因中占有重要地位;临床发病时ICA、IAA阳性可以作为IDDM自身免疫的标志,但不能反映胰岛β细胞功能损害的程度。
In this study, we measured serum levels of islet cell antibody (ICA), serum insulin autoantibodies (IAA), serum C-peptide and insulin levels in 36 newly diagnosed IDDM patients without exogenous insulin and 72 newly diagnosed NIDDM patients 36 normal people as a control. Studies have shown that: autoimmunity plays an important role in the etiology of IDDM; ICA and IAA positive can be used as markers of IDDM autoimmunity at clinical onset, but it can not reflect the extent of pancreatic islet β cell dysfunction.