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采用酶标免疫测定法对３２例肝硬化脾功能亢进患者、３９例健康献血员及３１例特发性血小板减少性紫癜（ＩＴＰ）患者进行血小板相关抗体（ＰＡＩｇＧ、ＰＡＩｇＭ和ＰＡＩｇＡ）的检测。结果：肝硬化脾亢患者血小板相关抗体的异常率为４６．８８％，ＩＴＰ患者的异常率为７０．９７％。提示病理免疫机制部份地参与肝硬化脾亢患者血小板异常的作用。肝硬化脾亢患者的血小板抗体与血小板计数无相关性。
Platelet-associated antibodies (PAIgG, PAIgM and PAIgA) were detected by enzyme-linked immunosorbent assay in 32 patients with cirrhosis and hypersplenism, 39 healthy blood donors and 31 idiopathic thrombocytopenic purpura (ITP) patients. Results: The abnormal rate of platelet-associated antibody in patients with cirrhosis and hypersensitivity was 46.88%, and the abnormal rate of ITP was 70.97%. Suggesting that the pathological immune mechanism is partly involved in platelet abnormalities in patients with liver cirrhosis and hypersplenism. No correlation was found between platelet antibody and platelet count in cirrhotic patients with hypersplenism.