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目的对德州地区孕中期产前筛查和产前诊断,分析该地区缺陷胎儿的发生情况。方法对德州地区8701例妊娠15～20周的孕妇,采用时间分辨荧光分析法进行母血清甲胎蛋白(AFP)和游离绒毛膜促性腺激素β-亚基(β-hCG)二联筛查,对高风险孕妇进行羊水细胞培养和超声产前诊断。结果高风险孕妇检出率为7.63%,其中21-三体综合征(DS)为6.20%,18-三体综合征为0.69%,神经管畸形(NTDs)为0.74%。504例高风险孕妇中,产前诊断发现缺陷胎儿26例,阳性检出率为5.16%。结论产前筛查和产前诊断可以减少缺陷儿的发生,提高人口素质。
Objective To screen the prenatal screening and prenatal diagnosis in the second trimester of Texas area and analyze the incidence of defective fetuses in this area. Methods A total of 8701 pregnancies aged 15-20 weeks in Texas area were enrolled in this study. AFP and free β-hCG were screened by time-resolved fluorescence analysis. Amniotic fluid cell culture and ultrasound prenatal diagnosis of high-risk pregnant women. Results The detection rate of high risk pregnant women was 7.63%, including 6.20% of 21 trisomy, 0.69% of 18 trisomy and 0.74% of NTDs. Among 504 high-risk pregnant women, 26 cases were found with prenatal diagnosis of defective fetus, the positive rate was 5.16%. Conclusion Prenatal screening and prenatal diagnosis can reduce the incidence of defective children and improve the quality of the population.