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目的探讨EphB4蛋白在直肠癌组织中的表达及其临床意义。方法采用免疫组化SP法,检测73例直肠癌患者术后存档石蜡组织切片中EphB4的表达情况。结果EphB4蛋白在直肠癌中阳性表达率为49.32%。其表达水平与直肠癌浸润深度、淋巴结转移及临床TNM分期呈有密切关系,三因素组间差异均有统计学意义(P<0.05);而与性别、年龄、病理分化程度分组间无关(P>0.05)。结论EphB4蛋白在直肠癌组织中的表达与直肠癌患者的浸润深度、临床分期、有无淋巴结转移有关。提示EphB4可能参与了肿瘤生成发展过程,促进肿瘤进展。
Objective To investigate the expression of EphB4 protein in rectal cancer and its clinical significance. Methods The immunohistochemical SP method was used to detect the expression of EphB4 in paraffin embedded tissue sections of 73 patients with rectal cancer. Results The positive expression rate of EphB4 protein in rectal cancer was 49.32%. The expression level was closely related to the depth of invasion, lymph node metastasis and clinical TNM stage in rectal cancer. There were significant differences among the three factors (P <0.05), but not with gender, age and pathological differentiation (P > 0.05). Conclusion The expression of EphB4 protein in rectal cancer is related to the depth of invasion, clinical stage and lymph node metastasis in patients with rectal cancer. Tip EphB4 may be involved in the process of tumorigenesis, promote tumor progression.