论文部分内容阅读
为探讨各种细胞因子在幽门螺杆菌相关性胃肠粘膜病中的作用机理及意义 ,采用ELISA法 ,检测35例幽门螺杆菌阳性患儿血清IL_6、IL_8、IL_10水平 ,并与幽门螺杆菌阴性组31例作对照。结果显示两组间IL_6、IL_8分布水平差异有极显著性 (P<0.001) ;两组间IL_10分布水平差异有显著性 (P<0.05)。幽门螺杆菌阳性组与阴性组IL_6平均秩和之差为16.38,均数分别为108.46pg/ml及51.32pg/ml;IL_8平均秩和之差为34 ,均数分别为163.09pg/ml及92.36pg/ml;IL_10平均秩和之差为 -3.32 ,均数分别为12.56pg/ml及15.88pg/ml。幽门螺杆菌阳性组血清IL_6与IL_8间呈正相关 (r=0.349 ,P<0.001) ;IL_10与IL_6、IL_8间无明显相关性。提示细胞因子IL_6、IL_8、IL_10均参与了幽门螺杆菌感染后的致病过程 ;幽门螺杆菌感染胃肠粘膜产生的炎症反应损伤与IL_6、IL_8的过量产生有关 ,血清IL_10对炎症有抑制作用 ,从而为临床诊治幽门螺杆菌相关性疾病提供理论依据
To explore the mechanism and significance of various cytokines in Helicobacter pylori-associated gastrointestinal mucosal diseases, the levels of IL-6, IL-8 and IL-10 in serum of 35 H. pylori-positive children were detected by ELISA. Group of 31 cases as a control. The results showed that there was significant difference in the distribution of IL-6 and IL-8 between the two groups (P <0.001). The difference of IL-10 distribution between the two groups was significant (P <0.05). The difference between the mean rank sum of IL_6 of Helicobacter pylori positive group and negative group was 16.38, the average was 108.46 pg / ml and 51.32 pg / ml, respectively. The difference between the mean rank sum of IL_8 was 34.09, the mean were 163.09 pg / ml and 92.36 pg / ml; the difference between the average rank sum of IL-10 was -3.32, the mean were 12.56pg / ml and 15.88pg / ml, respectively. There was a positive correlation between IL_6 and IL_8 in Helicobacter pylori positive group (r = 0.349, P <0.001). There was no significant correlation between IL_10 and IL_6 and IL_8. It is suggested that the cytokines IL_6, IL_8 and IL_10 are involved in the pathogenesis of Helicobacter pylori infection. The inflammatory response induced by Helicobacter pylori infection in gastrointestinal mucosa is related to the excessive production of IL_6 and IL_8. The serum IL_10 may inhibit the inflammation, Thus providing a theoretical basis for clinical diagnosis and treatment of Helicobacter pylori-related diseases