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目的:比较膀胱癌患者及正常人尿液及血液中微量元素钙、镁含量的差异,研究膀胱癌相关危险因素。方法:选取76例膀胱癌患者为膀胱癌组和80名正常人为对照组,采集血清和尿液标本,并进行问卷调查。通过火焰原子吸收光谱法检测两组样本尿液及血清中的钙、镁元素。采用独立样本t检验比较两组的差异,问卷资料中相关危险因素用Logistic回归分析。结果:正常人组血清中的钙含量高于膀胱癌组(P=0.002),尿液中的钙和镁含量均低于膀胱癌组,P值分别为0.005和0.039,问卷调查提示服用非甾体抗炎药、吸烟和长期不良憋尿习惯是膀胱癌的危险因素,P值分别为0.000、0.004和0.000。结论:钙镁离子的代谢失衡和膀胱癌的发生发展有一定的相关性,服用非甾体抗炎药、吸烟和长期不良憋尿习惯在膀胱癌发生发展中是一危险因素。
OBJECTIVE: To compare the differences of trace elements calcium and magnesium in urine and blood of patients with bladder cancer and normal subjects and to study the risk factors of bladder cancer. Methods: Totally 76 bladder cancer patients were selected as bladder cancer group and 80 normal controls as control group. Serum and urine samples were collected and investigated by questionnaire. The contents of calcium and magnesium in urine and serum of two samples were detected by flame atomic absorption spectrometry. The independent sample t-test was used to compare the differences between the two groups. The relevant risk factors in the questionnaire data were analyzed by Logistic regression. Results: The serum calcium in normal people was higher than that in bladder cancer (P = 0.002). The contents of calcium and magnesium in urine were lower than those in bladder cancer (P = 0.005 and 0.039, respectively). Questionnaire suggested that non-steroid Body anti-inflammatory drugs, smoking and long-term poor holding back urine habits are risk factors for bladder cancer with P values of 0.000, 0.004 and 0.000, respectively. Conclusion: The metabolic imbalance of calcium and magnesium ions has some correlation with the occurrence and development of bladder cancer. Non-steroidal anti-inflammatory drugs, smoking and long-term adverse holding-back habits are a risk factor in the development of bladder cancer.