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[目的]回顾性分析后程适形放疗治疗Ⅲ期非小细胞肺癌(NSCLC)的近期疗效、无进展生存期及其影响因素。[方法]采用后程适形放疗治疗Ⅲ期NSCLC患者51例。放疗组10例接受常规放疗后行后程适形放疗;化放疗组41例接受2个周期化疗后行常规放疗和后程适形放疗。放疗总剂量56~70Gy。对近期疗效与无进展生存期的影响因素行单因素分析和多因素回归分析。[结果]51例患者总有效率为72.55%。单因素分析显示治疗前KPS评分是近期疗效的重要影响因素(P=0.015);年龄、治疗前KPS评分、病理学类型、是否化疗和近期疗效是无进展生存期的影响因素。多因素Cox回归模型分析显示近期疗效是无进展生存期的独立影响因素(P=0.030)。[结论]后程适形放疗治疗Ⅲ期NSCLC显示了较好的近期疗效。近期疗效是无进展生存期的独立影响因素。
[Objective] To retrospectively analyze the short-term effect, progression-free survival and its influencing factors of late course conformal radiotherapy for stage Ⅲ non-small cell lung cancer (NSCLC). [Method] Follow-up conformal radiotherapy for 51 patients with stage Ⅲ NSCLC. Radiotherapy group of 10 patients received conventional radiotherapy after the end of conformal radiotherapy; chemotherapy group of 41 patients received two cycles of chemotherapy followed by conventional radiotherapy and after conformal radiotherapy. The total dose of radiotherapy 56 ~ 70Gy. Factors affecting the recent efficacy and progression-free survival were analyzed by single factor analysis and multivariate regression analysis. [Results] The total effective rate of 51 patients was 72.55%. Univariate analysis showed that the KPS score before treatment was an important influencing factor in short-term efficacy (P = 0.015). Age, pre-treatment KPS score, pathological type, chemotherapy and short-term efficacy were the influencing factors of progression-free survival. Multivariate Cox regression model analysis showed that the short-term efficacy was an independent predictor of progression-free survival (P = 0.030). [Conclusion] Late conformal radiotherapy for stage Ⅲ NSCLC shows good short-term curative effect. Short-term efficacy is independent of progression-free survival.