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采用超声波法合成 2 - 18F- 2 -脱氧 -β- D-葡萄糖 (18F- FDG) ,以提高其合成效率。实验结果表明 :F取代前体 2位上亲核反应进行的程度与相转移催化剂和温度有关。无相转移催化剂时 ,84℃超声反应 10 min,亲核反应进行了 70 % ;而在 10 mg的 K2 .2 .2存在下 ,室温 (2 2℃ )下超声反应 10 min,亲核反应进行了 85 % ,在 84℃下超声反应 2 min,亲核反应进行了 95 %。同经典方法相比 ,超声波合成法 18F-利用率提高了 10 % ,反应管的放射性吸附下降了 5 %。超声法合成效率 (EOS)为 6 0 % ,校正校率 (EOB)为 78% ,合成时间为 4 0 min。仅用一根 C- 18纯化柱纯化 ,超声法合成的 18F- FDG中 18F-含量低于 1%。因此 ,采用超声波法合成 18F- FDG可明显提高合成效率
Ultrasound was used to synthesize 2 - 18F - 2 - deoxy - β - D - glucose (18F - FDG) to improve its synthesis efficiency. The experimental results show that the degree of nucleophilic reaction on the 2-position of F-substituted precursor is related to the phase transfer catalyst and temperature. In the absence of phase transfer catalyst, the reaction was carried out at 84 ℃ for 10 min and the nucleophilic reaction was carried out at 70%. The reaction of nucleophilic reaction was carried out for 10 min at room temperature (22 ℃) in the presence of 10 mg K2.2.2 at 85 ℃ %, Ultrasonic reaction at 84 ℃ for 2 min, the nucleophilic reaction was 95%. Compared with the classical method, the ultrasonic synthesis 18F-utilization rate increased by 10%, the reaction tube radioactive adsorption decreased by 5%. The ultrasonic synthetic efficiency (EOS) was 60%, the corrected school rate (EOB) was 78% and the synthesis time was 40 min. Purified with only one C 18 purification column, 18F-FDG synthesized by sonication contained less than 1% 18F-content. Therefore, the use of ultrasonic synthesis of 18F-FDG can significantly improve the synthesis efficiency