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几个世纪以来,人们通常把肺看作是仅仅与气体交换有关的器官,现在应改变这种看法。据文献报导,肺与内分泌有密切关系,它参与肽、胺和前列腺素的释放、激活和抑制。另外,它还参与毒物的代谢转化。肺微粒体混合功能氧化酶所能催化的反应也是多种多样的,它的非特异性酶促反应的特点,特别是它所含的芳烃羟化酶(Aryl hydrocarbon hydroxylase)为解释多环芳烃的致肺癌性提供了有力的依据。这些研究对于阐明毒物在肺内代谢的过程,毒作用机理和寻找防治职业中毒的具体方法等均有很大的理论和实践意义。一、肺是一个具有代谢毒物能力的器官研究哺乳动物肺混合功能氧化酶和毒物代谢的关系是受到肝微粒体混合功能氧化酶系研究的启发。1963年Garfinkel详细比较了肺
For centuries, the lungs have generally been regarded as organs that are merely related to gas exchange, which should now be changed. According to the literature, lung and endocrine are closely related, it is involved in peptide, amine and prostaglandin release, activation and inhibition. In addition, it is also involved in the metabolic transformation of poison. Lung microsomal mixed-function oxidase can catalyze a variety of reactions, its non-specific enzymatic reaction characteristics, in particular, it contains aromatic hydrocarbon hydroxylase (Aryl hydrocarbon hydroxylase) to explain the PAHs caused Lung cancer provides a strong basis. These studies have great theoretical and practical significance for elucidating the process of poison metabolism in the lungs, the mechanism of toxicity and the search for specific methods of prevention and treatment of occupational poisoning. First, the lungs are an organism with metabolic toxins. The study of mammalian lung-mixed-function oxidase and toxic metabolisms is inspired by the study of mixed-function oxidase systems in liver microsomes. Garfinkel compared the lungs in detail in 1963