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目的:观察小剂量克拉霉素治疗儿童慢性分泌性中耳炎的疗效。方法:将24例患儿(共有41患耳)分为克拉霉素组(12例、20耳)与对照组(12例、21耳),两组患者同时给0.5%麻黄素滴鼻,波氏球咽鼓管吹张2周,克拉霉素组同时口服克拉霉素,疗程为8周;对照组口服阿莫西林,疗程为2周。8周后对比观察两组的治疗效果。结果:克拉霉素组的治疗有效愈率为85.0%,显著高于对照组的33.3%(P<0.01);治疗后克拉霉素的听阈为(17.52±3.82)dB,显著好于对照组的(28.86±5.36)dB(P<0.01)。结论:长期低剂量口服克拉霉素治疗儿童慢性分泌性中耳炎效果较好。
Objective: To observe the curative effect of small dose clarithromycin on chronic otitis media with effusion in children. Methods: 24 children (41 ears) were divided into clarithromycin group (12 cases, 20 ears) and control group (12 cases, 21 ears). The two groups were treated with 0.5% ephedrine intranasal The eustachian tube blowing for 2 weeks, clarithromycin group oral Clarithromycin, treatment for 8 weeks; the control group oral amoxicillin, course of treatment for 2 weeks. After 8 weeks, the therapeutic effects of the two groups were compared. Results: The effective cure rate of clarithromycin group was 85.0%, which was significantly higher than that of the control group (33.3%, P <0.01). The clarithromycin threshold was (17.52 ± 3.82) dB after treatment, which was significantly better than that of the control group (28.86 ± 5.36) dB (P <0.01). Conclusion: Long-term low-dose oral clarithromycin treatment of chronic otitis media in children is better.