论文部分内容阅读
采取简单小室法，用离体小鼠皮肤进行体外透皮扩散试验，计算含不同促渗剂的２％ 酮洛芬凝胶的累积渗透量Ｑ 及渗透速率ｋ。比较其结果，１％ ～５％ 薄荷脑、１％ ～５％ 氮酮对２％ 酮洛芬凝胶的累积渗透量Ｑ 及渗透速率ｋ 均显著地提高（Ｐ＜ ０．０１）；１０％ ～３０％ 丙二醇显著地降低２％ 酮洛芬凝胶的Ｑ与ｋ（Ｐ＜ ０．０１），并明显抑制薄荷脑、氮酮的促渗作用；薄荷脑与氮酮的联用并无联合增效作用。提示薄荷脑、氮酮可作为促渗剂在酮洛芬凝胶剂中单独使用。
Using a simple chamber method, in vitro mouse skin transdermal diffusion test to calculate the cumulative permeation Q of 2% ketoprofen gel with different penetration enhancers and infiltration rate k. Comparing the results, 1% ~ 5% menthol, 1% ~ 5% Azone on 2% ketoprofen gel cumulative permeation Q and infiltration rate k were significantly increased (P <0.01); 10% ~ 30% propylene glycol significantly reduced the Q and k (P <0.01) of 2% ketoprofen gel, and significantly inhibited the promoting effect of menthol and azone, while the combination of menthol and azone did not Synergy. Tip menthol, Azone can be used as a penetration enhancer in ketoprofen gel alone.