【摘 要】
：
In mammals, spinal cord injury (SCI) is a devastating event that can lead to a permanent loss of motor, sensory and autonomic functions below the site of injury
【机 构】
：
Department of Functional Biology, CIBUS, Faculty of Biology, Universidade de Santiago de Compostela,
论文部分内容阅读
In mammals, spinal cord injury (SCI) is a devastating event that can lead to a permanent loss of motor, sensory and autonomic functions below the site of injury. In the last years, the role of different neurotransmitter systems on re-generation and recovery from SCI has been deciphered. For example, studies in lampreys have shown that neurotransmitters play a key role in modulating the survival and regeneration of brainstem descending neurons after SCI (Ro-maus-Sanjurjo et al., 2018; Sobrido-Cameán et al., 2018). Glutamate is known to play a prominent role after SCI since it causes excitotoxicity to non-injured neurons during the secondary phase after a traumatic injury both in mam-mals and lampreys (Fández-López et al., 2014). In contrast, recent work in lampreys has shown that γ-aminobutyric acid (GABA) can play a neuro-protective and pro-regenerative role after SCI (Romaus-Sanjurjo et al., 2018). GABA is the main inhibitory neurotransmitter in the central nervous system (CNS) of vertebrates, and acts through both metabotropic G-protein-coupled GABAB receptors, and ionotropic ligand-gated chloride channel GABAA re-ceptors. Here, we discuss recent work from our group and others on the pos-sible role of different GABA receptors in neuronal survival and regeneration after SCI and provide a perspective on future work in this field.
其他文献
帕金森病认知障碍是严重影响老年人社会功能和生活质量的疾病，早期发现、早期诊断及早期治疗可明显改善其预后，并提高患者生活质量，因此对帕金森病认知障碍的早期识别尤为重要。
芳香族抗癫痫药物（aromatic antiepileptic drugs ，AAEDs）是临床抗癫痫治疗中常用的一类药物，较其他抗癫痫药物更易诱发皮肤不良反应（cutaneous adverse drug reactions ，cADRs），严重
Curcumin exerts a neuroprotective effect on Alzheimer’s disease; however, it is not known whether microRNAs are involved in this pro-tective effect. This study
MicroRNAs refer to a class of endogenous, short non-coding RNAs that mediate numerous biological functions. MicroRNAs regulate var-ious physiological and pathol
MicroRNAs (miRNAs) are small RNA molecules with important roles in post-transcriptional regula-tion of gene expression. In recent years, the predicted number of
Recent studies have shown the potential of artificially synthesized conduits in the repair of peripheral nerve injury. Natural biopolymers have received much at
The pathological implication of amyloid precursor protein (APP) in Alzheimer’s disease has been widely documented due to its involvement in the generation of a
Perinatal hypoxic-ischemic encephalopathy is a leading cause of neonatal death and disability. Thera-peutic hypothermia significantly reduces death and major di
In recent years, a large number of differentially expressed genes have been identified in human umbilical cord mesenchymal stem cell (hUMSC) transplants for the
目的系统回顾抑郁症患者初级保健心理治疗有效性的现有可查证据，与一般护理或控制组进行对比，并对疗法类型和实施模式进行研究。方法通过检索MEDLINE、Embase、CENTRAL和PsycIN