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目的 探讨环磷酰胺冲击疗法治疗难治性肾病综合征的临床效果.方法 筛选2016年3月—2017年2月三门峡市中心医院确诊的60例难治性肾病综合征患者纳入本次研究, 依照随机数字表法分为观察组和对照组, 分别给予环磷酰胺冲击和激素治疗, 对比两组的临床效果.结果 试验组全部缓解率和总有效率分别为53.3％和93.3％, 明显优于参照组的23.3％和73.3％, 差异有统计学意义 (P＜0.05);两组不良反应发生率差异无统计学意义 (P＞0.05) .结论 对于难治性肾病综合症患者实施环磷酰胺冲击疗法结合激素治疗, 可提高临床效果, 并且不良反应没有升高, 值得临床推广.“,”Objective To study the clinical effect of cyclophosphamide pulse therapy for refractory nephrotic syndrome.Methods Screening of 60 cases of refractory nephrotic syndrome diagnosis included in this study, the groups according to random number table method, namely, control group and test group were given ring hormone, cyclophosphamide pulse therapy, and hormone treatment, compared the clinical effect of the two groups. Results Treatment group total remission rate and total effective rate were 53. 3％ and 93. 3％ better than the control group were 23. 3％ and 73. 3％, the difference was statistically significant (P＜ 0. 05); No obvious difference in the two groups the incidence of adverse reactions, no statistical significance (P＞ 0. 05). Conclusion The implementation of cyclophosphamide pulse therapy in patients with refractory nephrotic syndrome combined with hormone treatment, can improve the clinical effect, and adverse reactions did not rise, worth clinical promotion.