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丙型肝炎病毒(HCV)感染后大多可引起持续性病毒血症和肝损伤,部分感染者可无明显表现,血清反应呈阴性。由于在HCV感染的人及动物黑猩猩,HCV多呈持续性感染,故对HCV保护性免疫机制的研究受到限制。作者在研究HCV特异性细胞毒性淋巴细胞(CTL)应答时,发现2名因职业原因可能接触HCV而无体液应答或病毒血症者,可产生HCV特异性CD4~+细胞和CD8~+细胞应答。
Most of the hepatitis C virus (HCV) infection can cause persistent viremia and liver damage, some patients may not have significant manifestations, serological reaction was negative. Because HCV is mostly persistent infection in HCV-infected humans and animal chimpanzees, the study of protective immunity against HCV is limited. In studying HCV-specific cytotoxic lymphocyte (CTL) responses, the authors found that HCV-specific CD4 ~ + and CD8 ~ + cell responses were found in 2 of those who may have been exposed to HCV for occupational reasons without a humoral response or viremia .