Up-regulation of muscarinic receptor of canine cerebral cortex by chronic treatment of a new anticho

• 出 处: 中国药理学与毒理学杂志
• 发表日期: 1989年03期
• 关键词: canine ethoxy cortex killed injected saline hydroxyl Twelve consecutive administ

Twelve dogs were divided into three groups. Group 1 and 2 were injected im 0.015 and 0.9mg/kg of3-(2’-phenyl-2’cyclopentyl-2’hydroxyl-ethoxy) quinuclidine (8018) daily respectively for consecutive twelveweeks. Group 3 (control) were injected im saline under the same conditions. All dogs were killed by bloodlettary

Group 1 and 2 were injected im 0.015 and 0.9 mg / kg of 3- (2’-phenyl-2’cyclopentyl-2’hydroxyl-ethoxy) quinuclidine (8018) respectively respectively for consecutive twelve weeks. Group 3 (control) were injected im saline under the same conditions. All dogs were killed by bloodlettary