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目的 探讨食道癌患者术后不同肠内营养方式的安全可行性和临床疗效。方法 食道癌患者 30例随机分为早期肠内营养组 (EPEN)和传统肠内营养组 (TEN) ,每组 15例。所有病例在术后第 1天、5天、9天分别测定血清白蛋白 (ALB)、前白蛋白 (PA)、转铁蛋白 (TF)和外周血淋巴细胞计数 (TLC) ,临床观察生命体征、胃肠道功能恢复情况以及各种不良反应。结果 所有病例在观察期间无死亡、无严重并发症、无明显肝肾功能改变 ;EPEN组较TEN组血清PA、TF、及TLC都明显升高 (P <0 0 5 ) ,而血清ALB水平未见明显改变。临床观察EPEN组较TEN组肛门排气早 (P <0 0 5 )。结论 食道癌患者术后早期应用肠内营养支持安全可行 ,既能改善营养状态 ,维护和促进胃肠道功能 ,也能提高机体免疫功能。
Objective To investigate the safety and clinical efficacy of different enteral nutrition after operation in esophageal cancer patients. Methods Thirty patients with esophageal cancer were randomly divided into early enteral nutrition group (EPEN) and traditional enteral nutrition group (TEN) with 15 cases in each group. Serum albumin (ALB), prealbumin (PA), transferrin (TF), and peripheral blood lymphocyte count (TLC) were measured on the first, fifth, and nine days after surgery in all cases. Clinical signs were observed. , gastrointestinal function recovery and various adverse reactions. Results There were no deaths, no serious complications, no obvious changes in liver and kidney function during the observation period in all cases. Serum PA, TF, and TLC in the EPEN group were significantly higher than those in the TEN group (P < 0.05), but serum ALB levels were not. See obvious changes. The clinical observation of EPEN group than the TEM group before the anus exhaust (P <0 05). Conclusion Early application of enteral nutrition support for patients with esophageal cancer is safe and feasible. It can not only improve nutritional status, maintain and promote gastrointestinal function, but also improve immune function.