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目的探讨依托咪酯、芬太尼与长托宁合用于无痛人流麻醉中的临床效果。方法选择平素体健的18~40岁女性200例(ASAⅠ-Ⅱ级),随机分为A、B两组,各100例。A组静注芬太尼+依托咪酯。B组先静推长托宁,20 min后再静推芬太尼+依托咪酯。术中分别观察记录2组呼吸抑制程度、血氧饱和度(SpO2)变化,肌阵挛发生率,唾液分泌量、宫颈松驰程度和清醒时间。结果与A组比较,B组用药后肌阵挛明显减少,口腔分泌量少,宫颈较松驰,手术时间短,清醒时间快。2组比较,差异均有统计学意义(P<0.05)。结论长托宁与依托咪酯、芬太尼合用于无痛人流,提高手术麻醉安全性,值得临床应用。
Objective To investigate the clinical effects of etomidate, fentanyl and trastuzumab in painless anesthesia. Methods 200 healthy women aged 18-40 years (ASAⅠ-Ⅱ grade) were selected and randomly divided into two groups (A and B), 100 cases each. Group A intravenous injection of fentanyl + etomidate. Group B, the first static long Tuoning, 20min and then push the intravenous fentanyl + etomidate. Respiratory depression, oxygen saturation (SpO2), myoclonus incidence, salivary secretion, cervical relaxation and awake time were recorded in the two groups during operation. Results Compared with group A, the myoclonus in group B was significantly reduced, the amount of oral secretions was less, the cervix was more relaxed, the operation time was shorter and the awake time was faster. The differences between the two groups were statistically significant (P <0.05). Conclusions Penehyclidine and etomidate, fentanyl combined for painless, to improve the safety of surgical anesthesia, it is worth clinical application.