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目的 评价S311治疗癌性胸腔积液的疗效及毒副作用。方法 经胸穿或闭式引流抽净胸水后 ,胸腔注入S3110 .32mg ,每周 1次 ,连续 3周 ,停药后观察 1个月评价疗效。结果 2 41例患者完成胸腔注入S311治疗 ,总有效率 92 .1%。主要的不良反应为发热和胸痛 ,发生率分别为 81.0 %和 5 2 .2 %。少数患者出现寒战、呼吸困难、恶心、呕吐 ,个别患者出现肝功能异常。结论 粘质沙雷氏菌菌苗 (S311)是一种治疗癌性胸腔积液的有效药物。
Objective To evaluate the efficacy and side effects of S311 in the treatment of cancerous pleural effusions. Methods After thoracic effusion was punctured or closed drainage, the thoracic cavity was injected with S3110.32mg once a week for 3 weeks, and the curative effect was observed after stopping for 1 month. Results Two hundred and forty-one patients completed the thoracic injection of S311 with a total effective rate of 92.1%. The main adverse reactions were fever and chest pain. The incidence was 81.0 % and 52. 2 %, respectively. A small number of patients experienced chills, dyspnea, nausea, and vomiting. Individual patients developed abnormal liver function. Conclusion Serratia marcescens (S311) is an effective drug for the treatment of cancerous pleural effusions.