microRNA-32 promotes white fat browning through augmenting FGF21 expression in brown adipose tissue

• 作 者: RaymondNG AttiqahNurulHUSSIAN
• 机 构: SingaporeInstituteforClinicalSciencesBrennerCentreforMolecularMedicine（A*STAR）30MedicalDrive
• 出 处: 中国药理学与毒理学杂志
• 发表日期: 2015年S1期
• 关键词: MICRORNA BROWN ADIPOSE tissue energy METABOLISM MA microRNA brown adipose tissue
• 基金项目: The project supported by Singapore Institute for Clinical Sciences(SICS)A*STAR Singapore and BMRC Young Investigator Grant

OBJECTIVE To investigate the effect of microRNA-32 on cold-induced thermogenesis and brown adipocyte energy metabolism.METHODS To apply the cold-induced thermogenesis model in mice,8-10 week old male C57Bl6 mice were placed within a 6℃fridge for 7d.Contro