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目的:探讨红景天对高原大鼠脑缺血损伤的神经保护作用。方法:采用红景天制剂给大鼠灌胃(治疗组)。造模30天后取各组的脑组织,采用HE染色和NISSL染色观察脑组织的形态学变化;免疫组织化学方法标记一氧化氮合酶(NOS),并进行分析。结果:对照组大鼠脑新皮质结构内NOS的阳性表达较正常组明显增高,治疗组的表达较对照组减少。结论:在低氧环境下红景天对脑缺血损伤的神经细胞有保护作用。
Objective: To investigate the neuroprotective effect of Rhodiola on cerebral ischemia injury in rats of plateau. Methods: Rhodiola was administered intragastrically to rats (treatment group). The brain tissue of each group was taken after 30 days of modeling. The morphological changes of brain tissue were observed by HE staining and NISSL staining. Nitric oxide synthase (NOS) was labeled by immunohistochemistry and analyzed. Results: The positive expression of NOS in the cerebral cortex of the control group was significantly higher than that of the normal group, and the expression in the treatment group was lower than that in the control group. CONCLUSION: Rhodiola rosea has neuroprotective effect on cerebral ischemia-injured neurons in hypoxic environment.