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目的观察经鼻持续气道正压通气(nCPAP)治疗对老年高血压病合并中重度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血小板活性及P选择素的影响。方法入选老年高血压病合并中重度OSAHS患者45例,按患者意愿及对nCPAP耐受情况,分为nCPAP治疗组及对照组,检测治疗前及治疗30d后血小板活性和P-选择素水平。结果nCPAP治疗30d后血清血小板活性和P-选择素较治疗前显著下降(P<0·001),对照组无明显变化(P>0·05)。结论nCPAP治疗可降低老年高血压病合并中重度OSAHS患者血小板活性及P-选择素水平。
Objective To observe the effect of nCPAP on platelet activity and P-selectin in elderly patients with hypertension and moderate-severe obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods Forty-five patients with senile hypertension and moderate and severe OSAHS were enrolled in this study. Patients were divided into nCPAP treatment group and control group according to their willingness and tolerance to nCPAP. Platelet activity and P-selectin level were measured before and 30 days after treatment. Results After 30 days of nCPAP treatment, serum platelet activity and P-selectin decreased significantly (P <0 · 001) and no significant change in control group (P> 0.05). Conclusion nCPAP treatment can reduce platelet activity and P-selectin levels in elderly patients with hypertension and moderate-severe OSAHS.