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酪酪肽(PYY)是1980年Mutt 实验室从猪小肠粘膜提取物中分离出的一种肽类激素,与胰多肽(PP)的结构十分相似,其生理作用尚未确定。最近,Taylor 实验室的Pappas 等在探讨PYY 的生理作用方面取得了一些新进展。他们首先确定了狗血浆PYY 浓度在肉餐后为86.3±8.5pM,用油酸灌注十二指肠后则为403±63pM,而静脉滴注100,200,400和800pM·kg~(-1)·h~(-1)剂量的PYY 分别使血浆PYY 浓度增至138±6、201±24、357±50和971±139pM。后三种剂量的PYY 可明显抑制进食引起的狗的胃酸、胰液
PYY, a peptide hormone isolated from the intestinal mucosal extracts of swine in Mutt’s lab in 1980, resembles the structure of pancreatic polypeptide (PP) and its physiological role has not yet been determined. Recently, Pappas et al. At Taylor Laboratory have made some new progress in exploring the physiological role of PYY. They first determined that dog plasma PYY concentrations were 86.3 ± 8.5 pM after meat meal and 403 ± 63 pM after oleate infusion into the duodenum while intravenous drip doses of 100, 200, 400 and 800 pM · kg -1 (-1) h ~ (-1) dose of PYY increased plasma PYY concentrations to 138 ± 6, 201 ± 24, 357 ± 50, and 971 ± 139 pM, respectively. After the three doses of PYY can significantly inhibit the feeding of dogs caused by gastric acid, pancreatic juice