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目的：观察米索前列醇用于防治产后出血的效果。方法：将３１３例产妇分为预防组和治疗组。预防组（２９７例）随机分为米索组（Ⅰ组），于第二产程宫缩可见胎头２～３ｃｍ大小时口服米索０．４ｍｇ，Ⅱ组米索加催产素组，米索用法同前，胎儿前肩娩出后即静脉注射催产素１０单位；Ⅲ组催产素加麦角组，催产素用法同前，同时肌注麦角０．２ｍｇ。治疗组１６例，均为已用催产素及麦角后２ｈ阴道出血量≥２５０ｍｌ时，给予口服米索０．６ｍｇ。结果：预防组中服米索的Ⅰ、Ⅱ组产后２ｈ出血量分别比催产素加麦角组减少７９．１３ｍｌ和８３．７６ｍｌ（Ｐ＜０．０１）。治疗组经口服米索０．６ｍｇ后１０ｍｉｎ阴道流血明显减少。结论：米索具有较催产素、麦角更强的宫缩作用，吸收快、方便、安全，可以较好地预防和治疗产后出血。
Objective: To observe the effect of misoprostol in preventing postpartum hemorrhage. Methods: 313 pregnant women were divided into prevention group and treatment group. Prevention group (297 cases) were randomly divided into misoprostol (Ⅰ group), contractions in the second stage of labor can be seen when the size of fetal head 2 ~ 3cm misoprostol 0.4mg, Ⅱ group misoprostol oxytocin group, misoprostol The same as before, the anterior fetal shoulder after intravenous oxytocin 10 units; Ⅲ oxytocin group plus oxytocin group, oxytocin with the former, at the same time intramuscular ergot 0.2mg. Treatment group of 16 patients, both have used oxytocin and ergot 2h vaginal bleeding ≥ 250ml, given oral misoprostol 0.6mg. Results: In the prophylaxis group, the amounts of bleeding in group Ⅰ and group Ⅱ after administration of misoprostol were 79.13 ml and 83.76 ml less than those in oxytocin and adriamycin group respectively (P <0.01). The treatment group by vaginal administration of misoprostol 0.6mg 10min after vaginal bleeding was significantly reduced. Conclusion: Misoprostol has stronger contractility than oxytocin and ergosterol. It has the advantages of fast, convenient and safe absorption and can prevent and treat postpartum hemorrhage.