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目的：探讨高原移居人群低氧初期和居住６个月后的动态肺功能与血浆一氧化氮之间的内在关系，充分认识低氧环境中肺通气功能的变化和调节过程，为急性高原病的防治寻求新的途径；方法：采用美国产ＥＳ８００ 肺功能仪对同一群体的２０名男性健康青年于上山前（海拔１ ４００ｍ ）和进驻海拔５ ３８０ｍ １０ 天及居住６ 个月后在静息状态下进行动态肺功能及血浆一氧化氮的测定；结果：海拔５ ３８０ｍ 移居１０ 天与海拔１ ４００ｍ 比较，ＦＶＣ（用力肺活量）、ＦＥＦ２５％ ～７５％ （用力呼气中期流速）、ＦＥＶ１（１ 秒钟用力呼气量）及ＭＶＶ（最大通气量）显著增加（Ｐ＜ ０．０１ 或Ｐ＜ ０．０５），血浆ＮＯ（一氧化氮）含量显著降低（Ｐ＜ ０．０１），海拔５ ３８０ｍ 居住６ 个月与移居１０天比较，ＦＶＣ、ＭＶＶ显著降低（Ｐ＜ ０．０５），血浆ＮＯ含量显著增多（Ｐ＜ ０．０５）；海拔５ ３８０ｍ 居住６ 个月与海拔１ ４００ｍ 比较ＦＶＣ、ＦＥＦ２５％ ～７５％ 、ＦＥＶ、ＭＶＶ显著增加（Ｐ＜ ０．０１ 或Ｐ＜ ０．０５），血浆ＮＯ显著降低（Ｐ＜０．０５）；海拔５ ３８０ｍ 移居６ 个月与移居１０ 天比较，ＰＥＦ（最大呼气流量）、ＦＥＶ１％ （１ 秒钟用力呼气量占用肺活?
OBJECTIVE: To explore the intrinsic relationship between dynamic lung function and plasma nitric oxide in the initial stage of hypoxia and residence of 6 months in high altitude migrant population, fully understand the change and regulation process of pulmonary ventilation in hypoxia environment, Prevention and treatment to seek new ways; Methods: USES ES800 lung function of the same group of 20 male healthy youth before going uphill (elevation 1,400m) and stationed at an altitude of 5 380m 10 days and living 6 months after the resting state (FVC), FEF25% ~ 75% (forced expiratory mid-term flow), FEV1 (1 second Forced expiratory volume) and MVV (maximal ventilation) (P <0.01 or P <0.05), plasma NO (NO) content was significantly lower (P <0.01) 6 months compared with 10 days of emigration, FVC, MV V significantly (P <0.05) and plasma NO content increased significantly (P <0.05). Compared with the altitude of 1400 m, the FVC, FEF 25% -75%, FEV, (P <0.01 or P <0.05), plasma NO significantly decreased (P <0.05); PEF (maximum expiratory flow), FEV1% (1) Second forced expiratory volume take lung live?