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目的结合年龄探讨抗苗勒氏管激素(anti-müllerian hormone,AMH)筛查在孕前保健中的应用价值。方法将2015年4月至2015年9月于成都市妇女儿童中心医院妇女保健中心进行孕前保健检查的1 426例25~40岁妇女分为25~30岁、31~35岁、36~40岁3组,采用血清AMH筛查,分析检验结果。结果 1 426例受检者AMH水平随年龄增长逐渐降低,3组比较差异有统计学意义(P<0.05);36~40岁AMH<1.1 ng/m L的比例显著高于其他两组,差异有统计学意义(P<0.05);1 426例受检者中有不孕症者184例,占总筛查人数的12.9%;其AMH<1.1ng/m L的比例明显高于其他孕前检查者,差异有统计学意义(P<0.05)。结论在孕前保健中,35岁以上的妇女通过筛查血清AMH水平,有助于提高隐匿性卵巢储备功能降低的检出率,以促进妇女进行更合理的生育规划及指导不孕症治疗方案的决策。
Objective To investigate the value of anti-müllerian hormone (AMH) screening in pre-pregnancy health care in combination with age. Methods A total of 1 426 women aged 25-40 who underwent pre-pregnancy health checkup at the Women’s Health Center of Chengdu Women and Children’s Hospital from April 2015 to September 2015 were divided into 25-30 years old, 31-35 years old and 36-40 years old 3 groups, using serum AMH screening, analysis of test results. Results The level of AMH in 1 426 subjects decreased gradually with age, the difference was statistically significant in 3 groups (P <0.05), and the AMH <1.1 ng / m L in 36-40 years was significantly higher than the other two groups (P <0.05). There were 184 cases of infertility in 1 426 cases, accounting for 12.9% of the total number of cases. The proportion of AMH <1.1ng / m L was significantly higher than that of other pre-pregnancy tests The difference was statistically significant (P <0.05). Conclusion In pre-pregnancy health care, women over the age of 35 through the screening of serum AMH levels, help to improve the detection rate of occult ovarian reserve reduction in order to promote women’s more reasonable fertility planning and guidance of infertility treatment programs decision making.