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结扎兔冠状动脉左室支致冠状动脉闭塞(简称冠脉闭塞)前静注利多卡因,可使冠脉闭塞后室颤发生时间显著缩短(p<0.01);硫代脯氨酸预防给药能拮抗之。冠脉闭塞后静注利多卡因,可引起室性心动过速;硫代脯氮酸能降低其发生率(p<0.05)。冠脉闭塞前后静注利多卡因,使缺血周边区有效不应期均延长,加重不应期分散;硫代脯氯酸能预防利多卡因这一效应。本实验提示,在急性心肌梗塞的早期,用利多卡因预防心律失常值得怀疑;而且,盲目增加利多卡因用量也是有害的。
Ligation of pre-injection lidocaine in the left coronary artery with left coronary artery occlusion led to a significant shortening of ventricular fibrillation after coronary occlusion (p <0.01); thioproline prophylaxis Can antagonize it. Intravenous lidocaine intravenous injection of lidocaine, can cause ventricular tachyarrhythmias; thiophene proline can reduce the incidence (p <0.05). Intravenous lidocaine intravenous infusion of lidocaine, the effective peripheral refractory period were extended, aggravating refractory period dispersion; Thiophiuric acid can prevent this effect of lidocaine. This experiment suggests that prophylaxis of arrhythmia with lidocaine is suspected in the early stages of acute myocardial infarction and that it is also detrimental to blindly increase the amount of lidocaine used.