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新氟喹诺酮衍生物 R- 7176 2 ,即 (± ) - 9-氟 - 3-氟甲基 - 2 ,3-二氢 - 10 - [4- (2 -吡啶基 ) - 1-哌嗪基 ]- 7-氧 - 7H-吡啶并 [1,2 ,3- de][1,4]苯并口恶嗪 - 6 -羧酸 ,对 型人免疫缺陷病毒 (HIV- )诱导性细胞病变具有保护作用 ,可抑制急性和慢性 HIV- 感染细胞中的病毒复制 ,而在相同的实验分析系统中 ,以前曾报道过的对 HIV- 诱导性细胞病变具保护作用的氧氟沙星、左氧氟沙星、环丙沙星、诺氟沙星和依诺沙星却未显示出保护作用。说明 R- 7176 2是一种新的 HIV- 复制的抑制剂 ,甚至对慢性 HIV- 感染细胞也有作用。
The new fluoroquinolone derivative R-7176 2, namely (±) -9-fluoro-3- fluoromethyl-2,3- dihydro- 10 - [4- (2-pyridyl) - 7-oxo-7H-pyrido [1,2,3-de] [1,4] benzoxazine-6-carboxylic acid has protective effect on human immunodeficiency virus (HIV-) induced cytopathic effect , Inhibits viral replication in both acute and chronic HIV-infected cells, whereas in the same experimental assay, ofloxacin, levofloxacin, and ciprofloxacin, previously reported to have protective effects against HIV-induced cytopathic effect, Star, norfloxacin and enoxacin showed no protective effect. Description R-7176 2 is a novel inhibitor of HIV-replication and even has effects on chronic HIV-infected cells.