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目的观察左卡尼汀治疗维持性血液透析患者并慢性心力衰竭的疗效。方法 46例维持性血液透析合并慢性心力衰竭患者随机分为对照组和治疗组,每组23例,治疗组在每次透析结束前,将左卡尼汀1.0 g稀释于10 ml生理盐水中缓慢推注;对照组于透析结束前推注20 ml生理盐水。比较两组治疗前后临床疗效及心功能指标的变化。结果治疗组临床疗效较对照组明显,差异有统计学意义(P<0.05),治疗后治疗组心功能指标改善较对照组更明显,差异有统计学意义(P<0.05)。结论左卡尼汀对维持性血液透析合并慢性心力衰竭患者疗效确切,对患者心功能有明显的改善。
Objective To observe the efficacy of levocarnitine in patients with chronic hemodialysis and chronic hemodialysis. Methods 46 patients with maintenance hemodialysis combined with chronic heart failure were randomly divided into control group and treatment group, with 23 cases in each group. The treatment group was diluted with 1.0 g of levocarnitine in 10 ml of normal saline before the end of each dialysis Bolus; control group before the end of dialysis bolus 20 ml saline. The changes of clinical curative effect and cardiac function before and after treatment were compared between the two groups. Results The clinical efficacy of the treatment group was significantly higher than that of the control group (P <0.05). After treatment, the improvement of cardiac function in the treatment group was more obvious than that in the control group (P <0.05). Conclusion L-carnitine has definite curative effect on patients with maintenance hemodialysis and chronic heart failure.